Membrane Attack Complex (MAC) and the CD59 inhibitor | Molecular Animation

This animation illustrates how CD59 binds to complement proteins C8 and C9 to prevent membrane perforation, based on research from the Bubeck Lab at Imperial College London.

Included as a supplementary information in:
Noone, D. P. & Bubeck, D “Advances in cryo-EM that have shaped mechanistic models of membrane-attack-complex assembly and regulation" IUCrJ (2026)
🔗 https://journals.iucr.org/m/issues/2026/03/00/eh5025/index.html

Research Citation:
Couves, E.C., et al. "Structural basis for membrane attack complex inhibition by CD59." Nature Communications (2023).
🔗 https://www.nature.com/articles/s41467-023-36441-z

Affiliation:
Department of Life Sciences, Imperial College London.
🔗 https://profiles.imperial.ac.uk/d.bubeck

Tools Used:
• Blender: 🔗 https://www.blender.org/
• Molecular Nodes: Created by Brady Johnston 🔗 https://bradyajohnston.github.io/MolecularNodes/

Credits:
• Animation & Visuals: Cleo Zhang
• Scientific Supervision: Professor Doryen Bubeck
• Technical Support: Jecky Zhang
• Emotional Support: Usoway (my cat)
• Production Assistance: Google Gemini
• Voiceover: Generated via TTSMaker

Видео Membrane Attack Complex (MAC) and the CD59 inhibitor | Molecular Animation канала CleoZArt