Computational Vascular Models: A Multiscale Framework for Health and Disease

Rebecca Shipley (University College London )
Keynote Lecture, Thursday June 5th, 2025, 09:30-11:00

Abstract
The development of robust multiscale vascular models holds transformative potential, both to contribute to our understanding of how tissues function in health and disease, and also across a wide range of clinical applications including diagnostics and therapeutics. In this talk, I will present a comprehensive framework for constructingtraction of novel multiscale computational models that capture complex vascular architectures, mechanics and associated delivery processes for solutes and therapeutics. A key feature of this approach is the integration of imaging data at multiple time and length scales, both to inform model parameterization and to validate model outputs against experimental and clinical observations. By incorporating data from modalities such as MRI, PET, and high-resolution microscopy, we enhance model accuracy and enable the eximaging biomarkers directly from simulated vascular dynamics. This fusion of computational modeling with imaging analytics not only improves model fidelity but also opens new avenues for non-invasive diagnostic and prognostic assessment.

Applications of these multiscale vascular models span oncology, where they predict tumor perfusion and drug delivery, nervous system tissue engineering, where they inform regenerative strategies, and obstetric healthcare, where they model placental blood flow to identify pathological conditions. I present case studies spanning these clinical domains and future challenges and opportunities.

Biosketch

Professor Rebecca Shipley expertise lies in computational modelling in healthcare as well as healthcare innovation. She has pioneered model-based techniques to better understand how diseased and damaged tissues function and repair, including in cancer and nerve injury, as well as data-driven models in physiology and digital health technologies. She is a passionate advocate for healthcare engineering and the translation of scientific discoveries into practice. During the pandemic, Rebecca co-led the UCL-Ventura programme, which delivered non-invasive ventilators in the UK and globally. Rebecca led the UCL Institute of Healthcare Engineering during between 2018 and -2024 and now is Chief Research Officer at UCLPartners.

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