Opioid Analgesics Morphine Pharmacology by Dr Rajesh Gubba

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Opioid Analgesics - Morphine Pharmacology by Dr.Rajesh Gubba

MORPHINE — Morphine is the prototype opioid agent. It is a phenanthrene opioid that is less lipophilic than the synthetic opioids (eg, fentanyl, remifentanil, sufentanil, alfentanil), which results in a slower onset of action compared with other opioids (within 20 minutes) due to poor penetration of the blood-brain barrier. However, morphine has a long analgesic duration of four to five hours. For this reason, it is often selected to preemptively and/or urgently control postoperative pain.

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