#134 - James O’Keefe, M.D.: Preventing cardiovascular disease and the risk of too much exercise

James O’Keefe is a preventative cardiologist and bestselling author of The Forever Young Diet and Lifestyle. In this episode, James discusses cardiac physiology and what makes the human heart susceptible to disease. He provides evidence for what supports his approach to exercise--elucidating both positive and negative kinds of exercise for heart health. He also discusses the role of nutrition, specific nutrients, and pharmacological interventions to support heart and brain longevity.

We discuss:
00:00:00 - Intro
00:03:15 - James’ background and why he favors a preventative approach to cardiology
00:10:15 - Understanding atherosclerosis and the misconception that it’s a “plumbing problem”
00:21:15 - The danger in excessive exercise—a reverse J-shaped mortality curve
00:49:15 - The story of Micah True—a case study of excessive exercise
00:53:00 - The best kinds of exercise for longevity—The Copenhagen City Heart Study
00:58:45 - Being a more balanced athlete and finding the right exercise intensity
01:04:00 - Heart rate during exercise, resting heart rate, and other important metrics
01:09:45 - Nutrition for cardiovascular health
01:19:30 - Important nutrients: Magnesium, potassium, calcium, sodium, and collagen
01:24:15 - GLT2 inhibition for diabetes, cardio-protection, and general longevity
01:34:15 - GLP-1 agonists for weight loss and reducing cardiovascular risk
01:37:25 - Statins—mechanism of action, safety, and useful alternatives
01:45:45 - A 40-year view on cardiovascular risk, and the possibility of reversing arterial calcification
01:53:30 - Evidence for high dose EPA and DHA for the reduction of cardiovascular disease risk
01:59:00 - The impact of omega-3, curcumin, and other compounds on mental health and dementia
02:02:15 - James’ focus beyond cardiology

Show notes page: https://peterattiamd.com/jamesokeefe/

About:
The Peter Attia Drive is a weekly, ultra-deep-dive podcast focusing on maximizing health, longevity, critical thinking…and a few other things. With over 30 million episodes downloaded, it features topics including fasting, ketosis, Alzheimer’s disease, cancer, mental health, and much more.

Peter is a physician focusing on the applied science of longevity. His practice deals extensively with nutritional interventions, exercise physiology, sleep physiology, emotional and mental health, and pharmacology to increase lifespan (delay the onset of chronic disease), while simultaneously improving healthspan (quality of life).

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Видео #134 - James O’Keefe, M.D.: Preventing cardiovascular disease and the risk of too much exercise канала Peter Attia MD