New Omicron Variant XBB.1.5 just EXPLODED - Mutations, Prevention, Severity, Home Testing, Treatment
XBB.1.5 just EXPLODED in new cases now becoming the DOMINANT variant in the USA with close to 75% of new cases in the Northeast and 41% of new cases across the country. This has all happened over a matter of a few weeks!
https://covid.cdc.gov/covid-data-tracker/#new-hospital-admissions
XBB.1.5 is closely related to the recombinant Omicron variant XBB. It has additional mutations including the F486P mutation that has been shown to grant additional immune evasion and high binding to human cells.
https://www.cell.com/cell/pdf/S0092-8674(22)01531-8.pdf?_returnURL=https%3A%2F%2Flinkinghub.elsevier.com%2Fretrieve%2Fpii%2FS0092867422015318%3Fshowall%3Dtrue
It seems to have a similar degree of immune evasion with both vaccinated and previously infected individuals as compared to XBB. Although it does also seem to bind to human cell receptors with a higher affinity.
https://twitter.com/yunlong_cao/status/1607915571001307137/photo/1
https://erictopol.substack.com/p/a-new-variant-alert
Home antigen testing seems to mostly be adequate (as adequate as with previous variants at least - video linked below on this). Although there is an FDA warning on a home saliva test that no longer seems to be accurate for XBB.
https://www.fda.gov/medical-devices/coronavirus-covid-19-and-medical-devices/sars-cov-2-viral-mutations-impact-covid-19-tests#omicron
The bivalent BA.5 vaccine booster has the highest degree of protection against XBB and most likely XBB.1.5 compared with previous monovalent boosters, although still lowest for XBB as compared to other previous Omicron variants.
https://www.nejm.org/doi/full/10.1056/NEJMc2214293
Paxlovid most likely remains affective in treating XBB.1.5 given it's effectiveness against XBB and the lack of additional mutations in the protease of XBB.1.5. No available monoclonal antibodies seem to be effective.
https://www.nejm.org/doi/full/10.1056/NEJMc2214302
There doesn't seem to be anything to suggest it causes more severe disease. Interestingly though, the hospitalizations rate for the elderly in the Northeast does seem to be rising to a disproportionate degree suggesting a possible connection to XBB.1.5.
https://covid.cdc.gov/covid-data-tracker/#new-hospital-admissions
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COLLECTION OF PLAYLISTS:
Critical Care Medicine 🚑
https://youtube.com/playlist?list=PLf5bMa9_tvRiZ85NNUGwk91YpqDWdIGvA&si=jGyrxrOcvQqTldFb
Pulmonology🫁
https://youtube.com/playlist?list=PLf5bMa9_tvRinTHdWwKFYBX7N5kfOBRHz&si=BKliNG26xrQqUNvx
Cardiology and ECG🫀
https://youtube.com/playlist?list=PLf5bMa9_tvRh2JoODgpLapjGDYXSW1q0h&si=jnr41duxoNnMw4ss
Nephrology🧂
https://youtube.com/playlist?list=PLf5bMa9_tvRgwXdcj18ux70r08Et93idU&si=tbOHFsPfZgFFZxWg
Acid Base🧬
https://youtube.com/playlist?list=PLf5bMa9_tvRjj4NDR0eq6M6TqKiZQZChX&si=iC0eBYNRCawR7f0G
Medical, Healthcare, and Science News📰
https://youtube.com/playlist?list=PLf5bMa9_tvRhsj4rBQzF7YOtboBoHL2u9&si=OBt6z2aJabzPoLeR
Biostatistics and Research📊
https://youtube.com/playlist?list=PLf5bMa9_tvRikRVVVVL09H-GxxrlJiZJh&si=vUO_j8D3VPqGAIAl
Immunology🧫
https://youtube.com/playlist?list=PLf5bMa9_tvRjLvJPC2ub_mLSxFmL7dNnt&si=RmbzEewJV1YU3PEx
Laboratory Evaluation and Values🧪
https://youtube.com/playlist?list=PLf5bMa9_tvRjGho7xcGieA1Hdkaj4vCCF&si=6cEOyuA8wuKcdpbp
Infectious Disease🦠
https://youtube.com/playlist?list=PLf5bMa9_tvRj4G9ApK7nw-7V2Ye31_MR9&si=C-_5_1x7RXrzaTMs
Obstetrics and Gynecology👶
https://youtube.com/playlist?list=PLf5bMa9_tvRgYRUdsBVEZ345SY0yYVEl9&si=A0SYAeK637NiMIdu
Procedures💉
https://youtube.com/playlist?list=PLf5bMa9_tvRiUYMZbBl-KBJJe2vyoeWyL&si=WJzDSnFd049JgHDc
Endocrinology🎂
https://youtube.com/playlist?list=PLf5bMa9_tvRgxyOVpxlkKAxsx4mtr6nGx&si=eiLnS5kDySGdHxMP
________________________________________________________________________
DISCLAIMER THIS VIDEO DOES NOT PROVIDE MEDICAL ADVICE. The information, including but not limited to, text, graphics, images and other material contained on this website are for informational purposes only. No material on this site is intended to be a substitute for professional medical advice, diagnosis or treatment. Always seek the advice of your physician or other qualified health care provider with any questions you may have regarding a medical condition or treatment and before undertaking a new health care regimen, and never disregard professional medical advice or delay in seeking it because of something you have read, watched, or listened to on this video, or any other videos, reports, texts tweets or other sources.
#xbb.1.5 #xbb #omicronvariants #covid19news #medicaleducation
Видео New Omicron Variant XBB.1.5 just EXPLODED - Mutations, Prevention, Severity, Home Testing, Treatment канала Whiteboard Medicine
https://covid.cdc.gov/covid-data-tracker/#new-hospital-admissions
XBB.1.5 is closely related to the recombinant Omicron variant XBB. It has additional mutations including the F486P mutation that has been shown to grant additional immune evasion and high binding to human cells.
https://www.cell.com/cell/pdf/S0092-8674(22)01531-8.pdf?_returnURL=https%3A%2F%2Flinkinghub.elsevier.com%2Fretrieve%2Fpii%2FS0092867422015318%3Fshowall%3Dtrue
It seems to have a similar degree of immune evasion with both vaccinated and previously infected individuals as compared to XBB. Although it does also seem to bind to human cell receptors with a higher affinity.
https://twitter.com/yunlong_cao/status/1607915571001307137/photo/1
https://erictopol.substack.com/p/a-new-variant-alert
Home antigen testing seems to mostly be adequate (as adequate as with previous variants at least - video linked below on this). Although there is an FDA warning on a home saliva test that no longer seems to be accurate for XBB.
https://www.fda.gov/medical-devices/coronavirus-covid-19-and-medical-devices/sars-cov-2-viral-mutations-impact-covid-19-tests#omicron
The bivalent BA.5 vaccine booster has the highest degree of protection against XBB and most likely XBB.1.5 compared with previous monovalent boosters, although still lowest for XBB as compared to other previous Omicron variants.
https://www.nejm.org/doi/full/10.1056/NEJMc2214293
Paxlovid most likely remains affective in treating XBB.1.5 given it's effectiveness against XBB and the lack of additional mutations in the protease of XBB.1.5. No available monoclonal antibodies seem to be effective.
https://www.nejm.org/doi/full/10.1056/NEJMc2214302
There doesn't seem to be anything to suggest it causes more severe disease. Interestingly though, the hospitalizations rate for the elderly in the Northeast does seem to be rising to a disproportionate degree suggesting a possible connection to XBB.1.5.
https://covid.cdc.gov/covid-data-tracker/#new-hospital-admissions
👇DON'T MISS OUT - JOIN OUR PATREON COMMUNITY TODAY 👇
https://www.patreon.com/WhiteBoardMedicine
We appreciate the support!
📰👇SIGN UP FOR OUR FREE BIMONTHLY NEWSLETTER👍👍
https://whiteboarddoctor.m-pages.com/IAdAdI/wbdr-sign-up
Stay up-to-date on the most important medical, science, and healthcare news!
COLLECTION OF PLAYLISTS:
Critical Care Medicine 🚑
https://youtube.com/playlist?list=PLf5bMa9_tvRiZ85NNUGwk91YpqDWdIGvA&si=jGyrxrOcvQqTldFb
Pulmonology🫁
https://youtube.com/playlist?list=PLf5bMa9_tvRinTHdWwKFYBX7N5kfOBRHz&si=BKliNG26xrQqUNvx
Cardiology and ECG🫀
https://youtube.com/playlist?list=PLf5bMa9_tvRh2JoODgpLapjGDYXSW1q0h&si=jnr41duxoNnMw4ss
Nephrology🧂
https://youtube.com/playlist?list=PLf5bMa9_tvRgwXdcj18ux70r08Et93idU&si=tbOHFsPfZgFFZxWg
Acid Base🧬
https://youtube.com/playlist?list=PLf5bMa9_tvRjj4NDR0eq6M6TqKiZQZChX&si=iC0eBYNRCawR7f0G
Medical, Healthcare, and Science News📰
https://youtube.com/playlist?list=PLf5bMa9_tvRhsj4rBQzF7YOtboBoHL2u9&si=OBt6z2aJabzPoLeR
Biostatistics and Research📊
https://youtube.com/playlist?list=PLf5bMa9_tvRikRVVVVL09H-GxxrlJiZJh&si=vUO_j8D3VPqGAIAl
Immunology🧫
https://youtube.com/playlist?list=PLf5bMa9_tvRjLvJPC2ub_mLSxFmL7dNnt&si=RmbzEewJV1YU3PEx
Laboratory Evaluation and Values🧪
https://youtube.com/playlist?list=PLf5bMa9_tvRjGho7xcGieA1Hdkaj4vCCF&si=6cEOyuA8wuKcdpbp
Infectious Disease🦠
https://youtube.com/playlist?list=PLf5bMa9_tvRj4G9ApK7nw-7V2Ye31_MR9&si=C-_5_1x7RXrzaTMs
Obstetrics and Gynecology👶
https://youtube.com/playlist?list=PLf5bMa9_tvRgYRUdsBVEZ345SY0yYVEl9&si=A0SYAeK637NiMIdu
Procedures💉
https://youtube.com/playlist?list=PLf5bMa9_tvRiUYMZbBl-KBJJe2vyoeWyL&si=WJzDSnFd049JgHDc
Endocrinology🎂
https://youtube.com/playlist?list=PLf5bMa9_tvRgxyOVpxlkKAxsx4mtr6nGx&si=eiLnS5kDySGdHxMP
________________________________________________________________________
DISCLAIMER THIS VIDEO DOES NOT PROVIDE MEDICAL ADVICE. The information, including but not limited to, text, graphics, images and other material contained on this website are for informational purposes only. No material on this site is intended to be a substitute for professional medical advice, diagnosis or treatment. Always seek the advice of your physician or other qualified health care provider with any questions you may have regarding a medical condition or treatment and before undertaking a new health care regimen, and never disregard professional medical advice or delay in seeking it because of something you have read, watched, or listened to on this video, or any other videos, reports, texts tweets or other sources.
#xbb.1.5 #xbb #omicronvariants #covid19news #medicaleducation
Видео New Omicron Variant XBB.1.5 just EXPLODED - Mutations, Prevention, Severity, Home Testing, Treatment канала Whiteboard Medicine
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