Lecture On Biochemistry of Lipoproteins: Structure, Function, Types & Metabolism | MBBS | TSMC

Join Dr. Karan Pal Singh for a comprehensive biochemistry lecture on lipoproteins. This session delves into the fundamental aspects of lipoproteins, including their definition, intricate structure, vital functions, and classification. The lecture provides a detailed exploration of the metabolism of key lipoproteins, specifically chylomicrons and VLDL, and elucidates the roles of important enzymes and apoproteins in these pathways.

What you will learn in this lecture (in Hindi):

Introduction to Lipoproteins: Understanding what lipoproteins are – complex macromolecules of lipids and apoproteins (e.g., LDL, VLDL, HDL, chylomicrons) [00:04].
Structure of Plasma Lipoproteins: A look at their non-covalent assembly, with a hydrophobic core (triglycerides, cholesterol esters) and a hydrophilic surface (phospholipids, proteins, cholesterol) [00:35].
Functions of Lipoproteins: Their crucial role as transport vehicles for insoluble lipids in blood, delivering cholesterol and triacylglycerol (TAG) to tissues [02:04], and transporting both dietary (exogenous) and biosynthesized (endogenous) lipids [03:38].
Types of Lipoproteins: Detailed discussion on:
Chylomicrons: Synthesized in the intestine, transporting dietary lipids [06:03].
VLDL (Very Low-Density Lipoproteins): Synthesized in the liver, transporting endogenous triglycerides.
LDL (Low-Density Lipoproteins): Formed from VLDL, primarily transporting cholesterol.
HDL (High-Density Lipoproteins): Involved in reverse cholesterol transport.
Density, Composition, and Properties: Understanding how density varies across lipoprotein types based on their lipid and protein content [07:52] and a summary of their major core lipids and apoproteins [11:30].
Key Enzymes & Proteins in Lipoprotein Metabolism:
Lipoprotein Lipase (LPL): Its location, role in hydrolyzing TAG in chylomicrons and VLDL, Apo C-II activation, and insulin influence [15:56].
Lecithin Cholesterol Acyltransferase (LCAT): Association with HDL and cholesterol esterification [24:07].
Cholesteryl Ester Transfer Protein (CETP): Its role in lipid exchange between lipoproteins [24:29].
Apolipoproteins (Apoproteins): Their structural and functional significance, including receptor recognition and enzyme activation/inhibition (e.g., Apo C-II) [29:46].
Detailed Metabolism:
Chylomicron Metabolism: Assembly in intestinal cells, transport of dietary lipids, maturation with Apo C-II and Apo E from HDL, and interaction with LPL [33:29].
VLDL Metabolism: Biosynthesis in hepatocytes, transport of endogenous triglycerides, maturation, LPL action, and formation of IDL and LDL [45:48].
Visual & Teaching Style:
The lecture is supported by clear slides featuring text, diagrams (lipoprotein structure [00:11], metabolic pathways [45:34]), tables (lipoprotein types and properties [06:07, 11:30]), and graphs (density/composition [07:52]). Dr. Singh employs helpful analogies to explain complex concepts.

For Students:
Dr. Singh encourages active learning by prompting students to "take a picture" of important slides [11:52, 42:28] and "write down" key information [32:28]. He also advises reading up on chylomicron and VLDL metabolism before the next class on LDL metabolism [56:48].

This lecture is an excellent resource for biochemistry students, medical students, and anyone studying lipid metabolism who is comfortable with Hindi instruction.
TRIPURA SANTINIKETAN MEDICAL COLLEGE
Real Class room Demonstration/Lecture On: (BIOCHEMISTRY) LIPOPROTEIN I)
BY- DR. KARAN PAL SINGH
(MBBS Batch: 2024- 2025)
Conducted on:- 16-05-25

Видео Lecture On Biochemistry of Lipoproteins: Structure, Function, Types & Metabolism | MBBS | TSMC канала Tripura Santiniketan Medical College