Prospective, collaborative approaches to meta-analysis: latest updates

This webinar offered a sneak-preview of the soon to be published latest updates to the Cochrane Handbook chapter on prospective, collaborative approaches to evidence synthesis. Participants learned about prospective meta-analysis (PMA) and other collaborative approaches, including when to use them, their key advantages, and best practices for planning, conducting, reporting, and disseminating findings. Using practical examples, the session demonstrated strategies for systematically searching trial registries, harmonising study designs and outcomes across trials, and managing large, global collaborations effectively.

Dr Kylie Hunter is a Research Fellow and co-lead of the NextGen Evidence Synthesis Team at the NHMRC Clinical Trials Centre, University of Sydney. She is Associate Convenor of the Cochrane Prospective Meta-Analysis Methods Group and was recently elected to the Cochrane Methods Executive. Her research focuses on collaborative evidence synthesis methodologies, in particular, individual participant data and prospective meta-analysis. She has led methods innovations that have shaped Cochrane guidance and global best practice, including guidance for searching clinical trials registers and the development of an individual participant data integrity tool. Dr Hunter applies these innovative methods to address high-priority research questions, with a particular focus on child health.

Prof Anna Lene Seidler is Professor for Health Equity at University Medical Center Rostock and German Center for Child and Adolescent Health. She is also Honorary Affiliate at the NHMRC Clinical Trials Center at the University of Sydney, Honorary Principal Research Fellow at University College London, and Convenor and primary contact of the Cochrane Prospective Meta-Analysis Methods Group. Prof Seidler has made major research contributions to the field of methods development for next generation evidence synthesis approaches, such as prospective meta-analysis, and individual participant data meta-analysis. The next generation evidence synthesis approaches she develops are geared toward moving beyond the one-size-fits all approach and toward understanding differential health system needs for different population groups (e.g. by socio-economic position, for rural populations, or for Indigenous health).

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