Breast cancer patients get 'digital twins' to develop more effective treatments

(21 Nov 2023)
SPAIN BREAST CANCER

SOURCE: ASSOCIATED PRESS

RESTRICTIONS:

LENGTH: 6.37

ASSOCIATED PRESS
Madrid, Spain - 10 November 2023

1. Wide of cancer patient Yolanda Ramos with her dogs at home
2. Close of Ramos
3. Wide of Ramos with her dogs
4. SOUNDBITE (Spanish) Yolanda Ramos, cancer patient and participant in the `Digital Twins´ research project:
“I had breast cancer surgery once, during the first (cancer) and now nothing, there is no other operation (available), the metastasis is in my bones and now it is only treatment (that's available). When the treatment stops working, which is usually after six months, they change my treatment, and now I am on carboplatin (chemotherapy drug) and waiting for some tests to find out if it works or not.”

5. Wide of Ramos entering hospital where she receives cancer treatment
6. Ramos sitting on chair, doctor preparing chemotherapy treatment
7. Various of Ramos and doctor manipulating drip on Ramos'' chest
8. Various of doctor and Ramos
9. Doctor manipulating chemotherapy machine
10. Doctor arranging pillow for Ramos during chemo

ASSOCIATED PRESS
Madrid, Spain - 17 November 2023

11. Spanish National Cancer Research Centre (CNIO) exterior
12. SOUNDBITE (English) Miguel Quintela, Director, Clinical Research Programme, Spanish National Cancer Research Centre (CNIO):
“Mood, habits, nutrition, other omics, such as the microbiome, proteomics, plasma metabolomics, etc. So, there are many other factors other than tumour genes that also influence patient outcome. And we want to tackle all these data streams, bundle them up, merge them, and be able out of all these data streams be able to truly predict and manage patient course."

13. Breast Cancer Clinical Research Unit entrance at Spanish National Cancer Research Centre (CNIO)
14. Laboratory technician manipulating samples
15. Various of laboratory technician entering CNIO freezer room
16. Close of lab technician putting samples in freezer
17. Freezer at -76 degrees Celsius, sign reading (Spanish): "Clinical research programme. Breast cancer. Miguel Quintela"
18. SOUNDBITE (English) Miguel Quintela, oncologist and director of the Clinical Research Programme at the Spanish National Cancer Research Centre (CNIO):
“With a real patient, you cannot make tests, you just put a treatment and then you expect the outcome. So, if this patient digital model is accurate enough, you can simulate millions of disease trajectories resulting from modifying one patient factor or another, right. So that you are able to get, at the end of the day, a number of treatment decisions, individualized for that patient that would improve patient outcome.”

ASSOCIATED PRESS
Madrid, Spain - 10 November 2023

19. Close of chemotherapy treatment machine
20. Close of chemotherapy treatment
21. Close of bell that patients ring to celebrate the end of their treatment at Guadalajara Hospital

ASSOCIATED PRESS
Madrid, Spain - 17 November 2023

22. Setup shot of oncologist Lucía González-Cortijo in her office at Quirónsalud Hospital
23. SOUNDBITE (Spanish) Lucía González-Cortijo, Head of the Medical Oncology Department at Quirónsalud University Hospital, Madrid:
“When they integrate all this information, interesting data will surely emerge. I don't know if they will be able to be applied immediately or in the medium-term in our patients, but probably, by refining all this information and with a little more research, it will probably be possible to develop, I don't say new drugs, but perhaps different ways of administering the drugs we already know in oncology."

ASSOCIATED PRESS
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