Maraviroc Mechanism of Action (MOA)

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. Maraviroc Mechanism of Action (MOA)

Maraviroc is a potential antiviral drugs for the HIV-1 (R5 strain). Let’s review it’s mechanism of action. (See the side effects in the video and the description below. Also, review the references.)

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About serious side effects of Maraviroc (Reference: https://clinicalinfo.hiv.gov/en/drugs/maraviroc/patient)
Note: Maraviroc can cause serious, life-threatening side effects. These include liver problems and severe skin rash and allergic reactions.

References:
Maraviroc
https://en.wikipedia.org/wiki/Maraviroc
Book: Goodman and Gilman
Maraviroc blocks the binding of the HIV outer envelope protein gp120 to the CCR5 chemokine receptor
Brunton, Laurence; Knollman, Bjorn; Hilal-Dandan, Randa. Goodman and Gilman's The Pharmacological Basis of Therapeutics, 13th Edition (Goodman and Gilman"S the Pharmacological Basis of Therapeutics) . McGraw-Hill Education. Kindle Edition.
Location 54074

CCR5
https://en.wikipedia.org/wiki/CCR5
On monocytes
https://journals.lww.com/shockjournal/Fulltext/2019/11000/CCR5_Positive_Inflammatory_Monocytes_are_Crucial.16.aspx
CCR5 and Cytotoxic T cells
https://pubmed.ncbi.nlm.nih.gov/31034775/
CCR5 Receptor Antagonists
https://en.wikipedia.org/wiki/CCR5_receptor_antagonist#Drug_development
HIV.Gov
https://clinicalinfo.hiv.gov/en/drugs/maraviroc/patient
G-protein coupled receptors
https://en.wikipedia.org/wiki/G_protein-coupled_receptor
CCL5
https://en.wikipedia.org/wiki/CCL5
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Disclaimer:
This video is not intended to provide assessment, diagnosis, treatment, or medical advice; it also does not constitute provision of healthcare services. The content provided in this video is for informational and educational purposes only.
Please consult with a physician or healthcare professional regarding any medical or mental health related diagnosis or treatment. No information in this video should ever be considered as a substitute for advice from a healthcare professional. ...

Disclaimer:
This video is not intended to provide assessment, diagnosis, treatment, or medical advice; it also does not constitute provision of healthcare services. The content provided in this video is for informational and educational purposes only.
Please consult with a physician or healthcare professional regarding any medical or mental health related diagnosis or treatment. No information in this video should ever be considered as a substitute for advice from a healthcare professional. ...
Disclaimer:
This video is not intended to provide assessment, diagnosis, treatment, or medical advice; it also does not constitute provision of healthcare services. The content provided in this video is for informational and educational purposes only.
Please consult with a physician or healthcare professional regarding any medical or mental health related diagnosis or treatment. No information in this video should ever be considered as a substitute for advice from a healthcare professional.

Видео Maraviroc Mechanism of Action (MOA) канала Drbeen Medical Lectures