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Expert Cancer Panel: High-risk prostate ca w/ positive margin at seminal vesicle and negative PSAs

Recorded on 3/27/2021

56-year-old male with very high risk prostate cancer who underwent surgery revealing right seminal vesicle invasion,positive surgical margins, Gleason 3+3 disease at the positive margin, and extraprostatic extension, and negative post operative PSAs.

Summary:
- Patient presents with high-risk prostate cancer with positive surgical margins and extra-prostatic extension for management following radical prostatectomy. Post operative PSA is negative.
- Consider monitoring of PSA until post-op PSA value is greater than 0.1 ng/dL. At this point proceed to order PET/CT such as PSMA-directed PET and proceed with early salvage radiation treatment.
- Panelists also recommend consideration of adjuvant radiation therapy rather than salvage as RAVES and RADICALS-RT trials showed more favorable outcomes for adjuvant RT in patients with very high-risk prostate cancer.
- In both of these scenarios patients should be considered for a limited time course of androgen deprivation therapy.
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