MCTP2 Gene | Gene Mutation | Face Blindness | Turns Familiar Faces into Strangers | Drishti IAS

A simple joy, often taken for granted, is to unexpectedly run into a friend or a relative at a train station or market. Recognising a familiar face in an unfamiliar context or crowded place gives most of us unalloyed pleasure. We should give thanks to our MCTP2 gene for this ability. According to research published in this month’s issue of the journal Genetics, by researchers led by Ye Rao of Capital Medical University, Beijing, when this gene is mutated the ability to recognise faces is severely impaired. Individuals with the misfortune of carrying the mutant gene took much longer than is socially acceptable to recognise people with whom they were expected to be familiar — such as spouses, siblings, and children — while they confused strangers with familiar people. This disorder is called prosopagnosia, or face blindness. Its prevalence worldwide is estimated to be 1.8-2.9% in the general population. Prosopagnosia is one form of visual agnosia, or inability to identify everyday items just by looking at them. The MCTP2 gene is thus the first found to be required for a higher form of visual social cognition in humans.
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