"Interrupted" reprogramming with Yamanaka factors reverse epigenetic age | Steve Horvath

Yamanaka factors, a group of proteins that can reprogram differentiated (mature) cells into pluripotent stem cells, may be a therapeutically novel way to reverse cellular aging. Following an "interrupted" pattern of reprogramming where cells retain their cellular identity, rather than cross-differentiating to a different lineage or reverting to a stem cell, may allow a type of epigenetic return to youthfulness, but without the cellular identity crisis. When cells lose their cellular identity, Dr. Horvath explains, this carries some cancer risk. In support of this hypothetical approach, a study using a mouse model of premature aging showed that short-term expression of four of these factors ameliorated cellular and physiological hallmarks of aging and prolonged lifespan. Other research has demonstrated that resetting aging cells to a youthful state in animal models produced fewer signs of aging and longer lifespans. These findings suggest that reprogramming may one day be a viable anti-aging intervention for use in clinical settings. In this clip, Dr. Steve Horvath describes how cellular reprogramming transforms old cells into younger ones.

Watch the full interview here:
https://www.youtube.com/watch?v=A_aaBKubJnA

Original episode posted December 22nd, 2020.
#epigenetics #aging #stemcells

About FoundMyFitness: Rhonda Patrick has a Ph.D. in biomedical science from the University of Tennessee Health Science Center, and St. Jude Children’s Research Hospital. She also has a Bachelor’s of Science degree in biochemistry/chemistry from the University of California. She has done extensive research on aging, cancer, and nutrition.

It is Dr. Patrick’s goal to challenge the status quo and encourage the wider public to think about health and longevity using a proactive, preventative approach.

Learn more about Dr. Rhonda Patrick and her mission for FoundMyFitness at www.foundmyfitness.com

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