Cellular Transit System

1. Describe how and ‘why’ drugs are metabolised in the liver.
2. Explain the concepts of zero and first order metabolism, first pass metabolism.
3. Describe how metabolism and elimination of a drug determine plasma half life.
4. Define CYP enzyme substrates, inducers and inhibitors and describe how co-prescription of these may cause drug interactions.
5. Describe the role of the kidney in drug elimination.

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