Serotonin is often referred as the “happy hormone,” but this oversimplification ignores its complex

Serotonin is often referred as the “happy hormone,” but this oversimplification ignores its complex and sometimes harmful effects. Serotonin is not solely a mood booster, and in fact, plays a significant role in stress responses. High levels of serotonin have been shown to increase sensitivity to stress and amplify the body’s stress response. This might explain why, under certain conditions, elevated serotonin levels are associated with increased anxiety rather than calmness.

The perceived benefits of SSRIs (Selective Serotonin Reuptake Inhibitors) in treating depression may not stem from serotonin itself but from their ability to increase allopregnanolone—a neurosteroid that enhances GABA activity, promoting relaxation and reducing anxiety. GABA is the brain’s primary inhibitory neurotransmitter, essential for calming the nervous system. This suggests that the therapeutic effects of SSRIs could be tied more to their downstream effects on neurosteroids than serotonin elevation.

However, SSRIs are not without harm. Research has shown that prolonged use can lead to emotional blunting, increased anxiety in some individuals, and even dependency. Their impact on serotonin can dysregulate other systems, such as appetite, sleep, and sexual function. Despite solid scientific evidence of these risks dating back decades, the “happy hormone” narrative persists. Its important to fully understand the effects of SSRIs before taking them and to approach mental health treatment with a holistic view rather than relying solely on serotonin-focused interventions.

Видео Serotonin is often referred as the “happy hormone,” but this oversimplification ignores its complex канала Leigh Erin Connealy MD