A Farmer Mistakenly Drank His Own Herbicide. This Is What Happened To His Brain.

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These cases are patients who I, or my colleagues have seen. They are de-identified and many instances have been presented in more depth in an academic setting. These videos are not individual medical advice and are for general educational purposes only. I do not give medical advice over the internet.

References:

Tox and Hound – Fellow Friday – Bipyridyl Herbicide Poisonings: Diquat and Paraquat. https://toxandhound.com/toxhound/ff-di-paraquat/

High-dose diquat poisoning: a case report. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8246526/

Urine sodium dithionite test: a useful clinical test for paraquat poisoning. https://journals.lww.com/jcsr/fulltext/2020/09030/urine_sodium_dithionite_test__a_useful_clinical.11.aspx

Human and experimental toxicology of diquat poisoning: Toxicokinetics, mechanisms of toxicity, clinical features, and treatment. https://pubmed.ncbi.nlm.nih.gov/29569487/

Case series: Diquat poisoning with acute kidney failure, myocardial damage, and rhabdomyolysis. https://www.frontiersin.org/articles/10.3389/fpubh.2022.991587/full

Diquat causes caspase-independent cell death in SH-SY5Y cells by production of ROS independently of mitochondria. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4572080/

Human and experimental toxicology of diquat poisoning: Toxicokinetics, mechanisms of toxicity, clinical features, and treatment. https://journals.sagepub.com/doi/10.1177/0960327118765330

Ferroptosis: past, present and future. https://www.nature.com/articles/s41419-020-2298-2

Where ferroptosis inhibitors and paraquat detoxification mechanisms intersect, exploring possible treatment strategies. https://pubmed.ncbi.nlm.nih.gov/32061663/

Methylene blue attenuates acute liver injury induced by paraquat in rats. https://www.sciencedirect.com/science/article/abs/pii/S1567576915002088

Case report: Successful outcome of a young patient with rhabdomyolysis and shock caused by diquat poisoning. https://www.frontiersin.org/articles/10.3389/fmed.2023.1116912/full

Bright Red Nuclei. https://n.neurology.org/content/62/4/619

Biochemical Mechanisms of Paraquat Toxicity. Anne P Autor. 1978.

Paraquat Poisoning. UpToDate.

Paraquat and Diquat. Michael Eddleston. Critical Care Toxicology. 2017. https://doi.org/10.1007/978-3-319-17900-1_10

Goldfrank's Toxicology.

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