Determination of the time and cause of death- Postmortem biochemical analysis

Biochemical profiles at autopsy may show considerable case variations due to various factors involving preexisting disorders, the cause of death, complications, the survival period, and postmortem changes, distributions and localizations of analytes. Postmortem interference may also be caused by various factors, including the status at the time of death, possible supravital reactions, leakage from cell deterioration, diffusion/redistribution, and analytical procedures. Thus, analyses of topographic distribution are also important. When these factors are taken into consideration, biochemical procedures provide useful findings for investigating the cause and process of death, contributory conditions, and predisposing disorders.

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