Bioengineered Neuronal Organoid activity mimics the fetal brain on the Maestro multiwell MEA system

Neural organoids on Axion's multiwell MEA system.

Learn more: https://www.axionbiosystems.com/resources/coffee-break-webinar-video/bioengineered-neuronal-organoid-activity-mimics-fetal-brain

Neural organoids, also known as mini brains, have emerged as a promising new model for studying the human brain. A neural organoid is a three-dimensional human stem cell-derived in vitro culture system that can be studied in a dish. Over time, they can develop complex neural activity that can be similar to the network function present in human fetal brains. This similarity can offer novel therapeutic approaches to neural disease modeling and drug development.

In this webinar, Dr. Zafeiriou, Application Specialist at the University Medical Centre at Göttingen, describes the progressive maturation of the neural network in BioEngineered Neuronal Organoids. Using Maestro MEA technology, Dr. Zafeiriou is able to detect complex neural network function that mimic early network activity similar to that of the fetal brain.

What is a multiwell MEA assay?
Axion’s microelectrode array (MEA), also known as multielectrode array, plates have a grid of tightly spaced electrodes embedded in the culture surface of each well. Electrically active cells, such as neurons, can be cultured over the electrodes. Over time, as the cultures become established, they form cohesive networks and present an electrophysiological profile. The resulting electrical activity, spontaneous or induced firing of neurons, is captured from each electrode on a microsecond timescale providing both temporally and spatially precise data.

Видео Bioengineered Neuronal Organoid activity mimics the fetal brain on the Maestro multiwell MEA system канала Axion BioSystems