New Studies of COVID 19 and Autopsy Report Analysis of a COVID 19 Patient

New Studies of COVID 19 and Autopsy Report Analysis of a COVID 19 Patient

Coronavirus is the virus responsible for the COVID 19 outbreak. Wuhan, China has been the epicenter of this epidemic, but some experts, like Dr. Anthony Fauci, are now saying that we are on the verge of a pandemic.

⏩ Timestamps, click to skip ahead!
00:00 - Introduction
01:00 - Current Positive COVID 19 Cases Details
02:05 - New Studies of COVID 19 and Autopsy Report Analysis of a COVID 19 Patient

Before I get to the Coronavirus autopsy report of a patient with COVID 19, it's important to understand the context of the numbers of total people infected, total people with COVID 19 pneumonia, the number of people who developed ARDS, and the total number of deaths.

When looking at the numbers, we should realize that they are almost certainly being underreported in China, and there are multiple reasons for that, which I won't get into right now.

Although these are not concrete numbers, it's what we have to go by at this point. The percentage of people.

Also, up to this point, there has not been any pathology reported on this disease because of limited access to autopsy and biopsy reports.

But finally, we now have a new case report study in Lancet Respir Med, published Feb 17, that has autopsy reports for a patient who died from COVID 19.

Pathological findings of COVID 19 associated with acute respiratory distress syndrome.

A patient is a 50-year-old man from China who visited Wuhan from Jan 8–12. On Jan 14, he developed a dry cough and some mild chills, day 1 of the illness. However, he did not initially seek medical attention and kept working until Jan 21. He then went to a medical clinic on Jan 21 because he had developed worsening symptoms by that time. He had fever, chills, fatigue, cough, and shortness of breath.
On Jan 22 (day 9 of illness), the Beijing Centers for Disease Control (CDC) confirmed by reverse real-time PCR assay that the patient had COVID 19.

He was immediately admitted to the isolation ward and received supplemental oxygen through a face mask.

He was given several different medications, including the inhaled version of interferon alfa-2b, lopinavir plus ritonavir as antiviral therapy, and Moxifloxacin, to prevent secondary bacterial infection.

He was also given a steroid, methylprednisolone, to attenuate lung inflammation.

On day 12 of illness, after the initial presentation, his symptoms did not improve, other than his fever, which he received medication for.

His chest x-ray on day 12 showed progressive bilateral infiltrates. He repeatedly refused ventilator support in the intensive care unit, apparently because he suffered from claustrophobia.

His oxygen saturation values decreased to 60%, and the patient had a cardiac arrest. At that point, he was intubated with mechanical ventilation; he had chest compressions and epinephrine.

Unfortunately, they are unable to revive him.

An autopsy is done, and biopsy samples were taken from the lung, liver, and heart.

The heart tissue was essentially normal.

The liver biopsy of this patient showed moderate microvascular steatosis and mild lobular and portal activity, indicating the injury could have been caused by either COVID 19 infection or, as a result, drug-induced liver injury.

Histological examination of lung tissue showed diffuse alveolar damage with Cellular Fibromyxoid exudates, along with the desquamation of pneumocytes and hyaline membrane formation.

These findings are consistent with acute respiratory distress syndrome (ARDS).

Interstitial mononuclear inflammatory infiltrates, dominated by lymphocytes, was seen in both lungs. There were multinucleated syncytial cells with atypical large alveoli characterized with prominent nucleoli, consistent with viral cytopathic-like changes.

These pathological features of COVID 19 greatly resemble those seen in SARS and Middle Eastern respiratory syndrome (MERS) coronavirus infection.

Acute Respiratory Distress Syndrome (ARDS)
To watch the video, please visit this link: https://youtu.be/INGKH7JnIpM.

Doctor Mike Hansen, MD
Internal Medicine | Pulmonary Disease | Critical Care Medicine
Website: https://doctormikehansen.com/
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Видео New Studies of COVID 19 and Autopsy Report Analysis of a COVID 19 Patient канала Doctor Mike Hansen