Deciphering the Alzheimer’s Enigma Using Technology | Or Shemesh | TEDxMIT

After decades of research, we still have not solved neuro-degenerative diseases (such as Alzheimer's disease, Parkinson's disease, ALS, CTE). The reason is lack of proper research tools. Now, through the engineering of novel technologies to study brain disease, we can understand and reverse these devastating conditions. Or will discuss the basic principles of this "counter disease-engineering" approach, and how they apply to different disorders. Having lost his grandfather to Alzheimer’s disease, Or Shemesh decided to study diseases of the nervous system. While completing his PhD in neuroscience, Or realized that he could not answer basic questions about the seeding cellular and molecular events that lead to pathology, due to the lack of proper technologies and methodologies to study the brain. To develop expertise in creating technologies, he joined MIT as a postdoc and learned the nuts and bolts of tool-building in the Synthetic Neurobiology Group. Nowadays, Or is starting his group as an Assistant Professor in the University of Pittsburgh, where he leads a team to invent novel technologies to study and reverse brain disease. In his talk, Or will describe the magnitude of the problem Alzheimer’s disease poses, why we failed in understanding the root causes of Alzheimer’s disease, and how technology can solve this looming threat to society. This talk was given at a TEDx event using the TED conference format but independently organized by a local community. Learn more at https://www.ted.com/tedx

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