Characterizing Amyloid-Forming IgG Light & Variable Chains with Microfluidic Modulation Spectroscopy
A deeper structural dive into light chain amyloidosis.
Protein structure is vitally important to function, however, loss in activity is not the only misfortune for misfolded proteins as they can also be immunogenic and disease-causing as in the case of amyloid plaques. Light chain amyloidosis results from the aggregation of the light chain in Immunoglobulin G (IgG) which is one of the most prevalent proteins in human serum.
In this webinar, we will cover the structural analysis of both light and variable chain domains of non-disease-causing IgGs from germline (GL), potential disease-causing domains from patients with multiple myeloma (MM), and disease-causing domains from amyloidosis patients (AL). Each sample was analyzed using Microfluidic Modulation Spectroscopy (MMS), a high-precision secondary structure characterization tool developed by RedShiftBio. Full structural characterization of IgG is important because the mechanism of aggregation is still unknown and further elucidation could lead to insights into potential treatments and cures.
Видео Characterizing Amyloid-Forming IgG Light & Variable Chains with Microfluidic Modulation Spectroscopy канала RedShiftBio
Protein structure is vitally important to function, however, loss in activity is not the only misfortune for misfolded proteins as they can also be immunogenic and disease-causing as in the case of amyloid plaques. Light chain amyloidosis results from the aggregation of the light chain in Immunoglobulin G (IgG) which is one of the most prevalent proteins in human serum.
In this webinar, we will cover the structural analysis of both light and variable chain domains of non-disease-causing IgGs from germline (GL), potential disease-causing domains from patients with multiple myeloma (MM), and disease-causing domains from amyloidosis patients (AL). Each sample was analyzed using Microfluidic Modulation Spectroscopy (MMS), a high-precision secondary structure characterization tool developed by RedShiftBio. Full structural characterization of IgG is important because the mechanism of aggregation is still unknown and further elucidation could lead to insights into potential treatments and cures.
Видео Characterizing Amyloid-Forming IgG Light & Variable Chains with Microfluidic Modulation Spectroscopy канала RedShiftBio
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