Response to James Tour: 700 Papers and Still Clueless (Part 2 of 2)

Last year I made a video about James Tour, a chemist and creationist who speaks out against origin of life research. He didn't like it much, so he decided to make a 14-part series about how dumb I am. He really pulled out all the stops, parading all of his classic fallacious talking points, with plenty of bald-faced lies and deliberate misrepresentations of scientific research peppered in for good measure. Honestly, I was rather shocked at how stupid it was. With so much material to work with, I ended up with quite a lot to say in response, and had to split it into two parts.

In this Part 2, we examine how James is lying about our progress towards prebiotic syntheses of all the major classes of biomolecules, and when it comes to cells, James would rather mislead his viewers with dazzling animations of modern eukaryotic cells than actually dig into the relevant literature. If you thought Part 1 was devastating, strap in.

Part 1 of this response: https://www.youtube.com/watch?v=ghJGnMwRHCs
My original video on James: https://www.youtube.com/watch?v=SixyZ7DkSjA

Research cited in this video:
Condensation of amino acids in water: https://link.springer.com/article/10.1007/s11084-006-9012-y
Amyloid aggregates from amino acid condensations: https://onlinelibrary.wiley.com/doi/abs/10.1002/anie.201605321
Lee's formation of oligopeptides: https://www.nature.com/articles/ncomms9385
Peptides by mechanochemistry: https://chemrxiv.org/articles/preprint/Mechanochemical_Prebiotic_Peptide_Bond_Formation/13187852
Bruce's peptide bond formation: https://pubs.acs.org/doi/abs/10.1021/acs.orglett.5b01812
Peptide bond half-life: https://pubs.acs.org/doi/abs/10.1021/ja00230a041
A route to enantiopure RNA precursors from nearly racemic starting materials: https://pubmed.ncbi.nlm.nih.gov/21860459/
Hydrothermal conditions at the origin of cellular life: https://www.liebertpub.com/doi/10.1089/ast.2015.1338
Lipid-assisted polymerization of nucleotides: https://www.mdpi.com/2075-1729/9/4/83
A defense of the RNA world hypothesis: https://www.researchgate.net/publication/229089462_The_RNA_world_hypothesis_The_worst_theory_of_the_early_evolution_of_life_except_for_all_the_others
Testing ideas in prebiotic analogue conditions: https://www.mdpi.com/2075-1729/11/2/134
The emergence of RNA from the heterogeneous products of prebiotic nucleotide synthesis: https://pubmed.ncbi.nlm.nih.gov/33636080/
Jack's nature.com article for laypeople: https://media.nature.com/original/magazine-assets/d41586-018-05098-w/d41586-018-05098-w.pdf
Lee and the formose reaction: https://chemistry-europe.onlinelibrary.wiley.com/doi/epdf/10.1002/syst.201900014
Breslow's autocatalysis: https://www.pnas.org/content/107/13/5723
Peptide-based organocatalysis: https://www.pnas.org/content/103/34/12713
Impressive 92-mer polysaccharide total synthesis: https://www.nature.com/articles/ncomms14851
Seeberger's automated glycan assembly: https://pubs.acs.org/doi/10.1021/jacs.0c00751
McCollum's lipid synthesis: https://link.springer.com/article/10.1023/A:1006592502746
The lipid world: https://link.springer.com/article/10.1023%2FA%3A1006746807104
Nick Lane and chemiosmosis: https://www.molevol.hhu.de/fileadmin/redaktion/Fakultaeten/Mathematisch-Naturwissenschaftliche_Fakultaet/Biologie/Institute/Molekulare_Evolution/Dokumente/188.pdf
Nick Lane on membrane divergence: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4130499/
Selection of prebiotic molecules in amphiphilic environments: https://www.mdpi.com/2075-1729/7/1/3
Full clip of Christian Mayer: https://www.youtube.com/watch?v=47anfKDONEU&feature=youtu.be
Vesicles and nucleic acid amplification: https://www.nature.com/articles/nchem.1127
Lee's protocells: https://www.nature.com/articles/s41467-017-00177-4.pdf

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