Muscle growth/strength versus endurance signal transduction pathways and their - Dr. Wackerhage

Invited Session "Concurrent training for peak power and endurance"

Muscle growth/strength versus endurance signal transduction pathways and their interaction
Wackerhage, H.
University of Aberdeen

In many sports athletes need to train for both strength/muscle mass and endurance. Equally muscle mass/high strength and high
endurance are associated with health and longevity. This provides a rationale for athletes and fitness-orientated exercisers to
increase strength/muscle mass and endurance at the same time. The aim of this presentation is to introduce a) a general theory of
adaptation to exercise, b) to introduce the signal transduction pathways that mediate skeletal muscle growth and endurance
adaptations in response to specific types of exercise and c) to highlight the interaction between these pathways. Key muscle growth
pathways are the mTOR and Smad pathways whilst endurance adaptations are regulated by the AMPK/CaMK-PGC-1α and
calcineurin NFAT pathways. These evolutionary highly conserved pathways also interact with each other and there is the evidence for
circadian behaviour.

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