The Ins and Outs of XP (Xeroderma pigmentosum)
Xeroderma Pigmentosum (XP) is a rare hereditary skin condition. It is the body’s extreme sensitivity to ultraviolet (UV) light due to the damage in the DNA repair mechanism. In this video, we will discuss what XP is, the DNA mechanism that causes XP, ongoing research to find a cure, as well as diagnosis, symptoms and disease management.
This video was made by McMaster students Mark Bertone, Jasmine Leung, Teja Koi and Maha Arif, in collaboration with the McMaster Demystifying Medicine Program.
Copyright McMaster University 2021.
References:
Alessi, S. S., Sanches, J. A., Oliveira, W. R. D., Messina, M. C., Pimentel, E. R. D. A., & Festa Neto, C. (2009). Treatment of cutaneous tumors with topical 5% imiquimod cream. Clinics, 64(10), 961-966.
American Society of Clinical Oncology (ASCO). (2020, April 30). Xeroderma Pigmentosum. Retrieved from
https://www.cancer.net/cancer-types/xeroderma-pigmentosum
Black, J. O. (2016). Xeroderma pigmentosum. Head and neck pathology, 10(2), 139-144.
Cleaver J. E. (2008). Diagnosis of Xeroderma Pigmentosum and Related DNA Repair-Deficient Cutaneous Diseases. Current medical literature. Dermatology, 13(2), 41–48.
DiGiovanna, J. J., & Kraemer, K. H. (2012). Shining a light on xeroderma pigmentosum. Journal of investigative dermatology, 132(3), 785-796
Kemp, M. G., & Sancar, A. (2012). DNA excision repair: where do all the dimers go?. Cell Cycle, 11(16), 2997-3002.
Lin, P., & English, J. C. (2004). Topical Treatment of Xeroderma Pigmentosum. P AND T, 29, 512-514.
Mareddy, S., Reddy, J., Babu, S., & Balan, P. (2013). Xeroderma pigmentosum: man deprived of his right to light. TheScientificWorldJournal, 2013, 534752. https://doi.org/10.1155/2013/534752
Mullenders, L. H., Stary, A., & Sarasin, A. (2001). Atlas of Genetics and Cytogenetics in Oncology and Haematology. Retrieved from http://atlasgeneticsoncology.org/Deep/ExcisRepairID20014.html
National Organization for Rare Disorders (NORD). (2017, August 04). Xeroderma Pigmentosum. Retrieved from
https://rarediseases.org/rare-diseases/xeroderma-pigmentosum/
Видео The Ins and Outs of XP (Xeroderma pigmentosum) канала Demystifying Medicine McMaster
This video was made by McMaster students Mark Bertone, Jasmine Leung, Teja Koi and Maha Arif, in collaboration with the McMaster Demystifying Medicine Program.
Copyright McMaster University 2021.
References:
Alessi, S. S., Sanches, J. A., Oliveira, W. R. D., Messina, M. C., Pimentel, E. R. D. A., & Festa Neto, C. (2009). Treatment of cutaneous tumors with topical 5% imiquimod cream. Clinics, 64(10), 961-966.
American Society of Clinical Oncology (ASCO). (2020, April 30). Xeroderma Pigmentosum. Retrieved from
https://www.cancer.net/cancer-types/xeroderma-pigmentosum
Black, J. O. (2016). Xeroderma pigmentosum. Head and neck pathology, 10(2), 139-144.
Cleaver J. E. (2008). Diagnosis of Xeroderma Pigmentosum and Related DNA Repair-Deficient Cutaneous Diseases. Current medical literature. Dermatology, 13(2), 41–48.
DiGiovanna, J. J., & Kraemer, K. H. (2012). Shining a light on xeroderma pigmentosum. Journal of investigative dermatology, 132(3), 785-796
Kemp, M. G., & Sancar, A. (2012). DNA excision repair: where do all the dimers go?. Cell Cycle, 11(16), 2997-3002.
Lin, P., & English, J. C. (2004). Topical Treatment of Xeroderma Pigmentosum. P AND T, 29, 512-514.
Mareddy, S., Reddy, J., Babu, S., & Balan, P. (2013). Xeroderma pigmentosum: man deprived of his right to light. TheScientificWorldJournal, 2013, 534752. https://doi.org/10.1155/2013/534752
Mullenders, L. H., Stary, A., & Sarasin, A. (2001). Atlas of Genetics and Cytogenetics in Oncology and Haematology. Retrieved from http://atlasgeneticsoncology.org/Deep/ExcisRepairID20014.html
National Organization for Rare Disorders (NORD). (2017, August 04). Xeroderma Pigmentosum. Retrieved from
https://rarediseases.org/rare-diseases/xeroderma-pigmentosum/
Видео The Ins and Outs of XP (Xeroderma pigmentosum) канала Demystifying Medicine McMaster
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19 января 2021 г. 2:00:11
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