[Sapphire Members Only] IgA Pemphigus: Histopathology, Clinical Features, and Management

#skin #blister #bullae #pemphigus #vulgaris #foliaceus #erosions #autoimmune #antibodies #autoantibodies #desmoglein #plakin #DIF #IIF #rituximab #paraneoplastic #iga

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Beginning - 01:00
Introduction - 01:57
Introduction: Synonyms - 03:34
Epidemiology - 04:09
Pathogenesis - 05:11
Pathogenesis: Desmocollins - 09:17
Diagnosis: Histopathology - 11:07
Diagnosis: Immunofluorescence - 15:34
Diagnosis: Complementary cDNA Transfection - 22:08
Diagnosis: Electron Microscopy - 25:25
Clinical Features: Types - 26:38
Clinical Features: IEN-Type vs SPD-Type - 27:56
Clinical Features - 29:45
Clinical Features: SPD-Type - 31:40
Clinical Features: IEN-Type - 33:15
Clinical Features: PF-Type and PF-Type - 34:20
Clinical Features: Undetermined-Type - 35:31
Clinical Features: Summarised - 36:05
Associated Disorders - 37:43
Differential Diagnosis - 38:34
Treatment - 39:12
IgG / IgA Pemphigus Variant - 41:41
Further Reading - 43:11
Membership to the Channel and SkinSire - 43:21
End - 44:54

Further Reading:

1. Chapter 50 – Immunobullous Diseases. In: Rooks Textbook of Dermatology, 10ed Pg-50.6, Schmidt E, Groves R.

2. Chapter 29 – Pemphigus. In: Bolognia’s Dermatology, 5ed Pg-509, Amagai M.

3. Chapter 57 – Intercellular Immunoglobulin (Ig) A Dermatosis (IgA Pemphigus). In: Fitzpatrick’s Textbook of Dermatology, 9ed Pg-981, Hashimoto T.

4. Aslanova M, Yarrarapu SNS, Syed HA, et al. IgA Pemphigus. [Updated 2024 May 1]. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2026 Jan-. Available from: https://www.ncbi.nlm.nih.gov/books/NBK519063/

5. Www. Pathologyoutlines.com
Tsuruta D, Ishii N, Hamada T et al. IgA pemphigus. Clin Dermatol. 2011 Jul-Aug;29(4):437-42.

6. L.Frasheri, M.Dechant, and T.Biedermann, “Therapeutic Options for IgA Pemphigus in Patients Refractory to Dapsone,” JEADV Clinical Practice0 (2026): e70310.

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