2. Approach and Management of Epidermolysis Bullosa - Part 2: Modalities for Treatment

Please watch part 1 before this video.

#basementmembrane #skin #butterflyskin #epidermolysisbullosa #skinattachment #epidermolysisbullosa #treatment #genetherapy #geneediting

B. Modalities for Treatment - 00:02
1. Recombinant Gene Therapy - 01:38
2. Recombinant Protein Therapy - 05:40
3. TALEN - 07:23
4. CRISPR-Cas9 System - 08:33
5. Transfer of Skin Grafts - 10:46
6. Fibroblasts - 12:38
7. Stem Cells - 15:05
8. Revertant Mosaicism - 16:29
9. Small Molecule Therapy - 19:21
C. Skin Carcinomas - 20:49
D. DEBRA - 23:27
Further Reading - 25:11
End - 26:27

Further Reading:

1. Chapter 69 – Genetic Blistering Disorders. In: Rooks Textbook of Dermatology, 10ed. Pg-69.1, Griffiths C et al.

2. Chapter 32 – Epidermolysis Bullosa. In: Bolognia’s Dermatology, 4ed. Pg-538, David Fine J et al.

3. Chapter 60 – Inherited Epidermolysis Bullosa. In: Fitzpatrick’s Dermatology, 9ed. Pg-1011, Marinkovish MP et al.

4. Shams F, Rahimpour A, Vahidnezhad H, Hosseinzadeh S, Moravvej H, Kazemi B, Rajabibazl M, Abdollahimajd F, Uitto J. The utility of dermal fibroblasts in treatment of skin disorders: A paradigm of recessive dystrophic epidermolysis bullosa. Dermatol Ther. 2021 Jul;34(4):e15028. doi: 10.1111/dth.15028. Epub 2021 Jun 28. PMID: 34145697.

5. Hou PC, Wang HT, Abhee S, Tu WT, McGrath JA, Hsu CK. Investigational Treatments for Epidermolysis Bullosa. Am J Clin Dermatol. 2021 Nov;22(6):801-817. doi: 10.1007/s40257-021-00626-3. Epub 2021 Jul 22. PMID: 34292508.

6. du Rand A, Hunt JMT, Feisst V, Sheppard HM. Epidermolysis Bullosa: A Review of the Tissue-Engineered Skin Substitutes Used to Treat Wounds. Mol Diagn Ther. 2022 Nov;26(6):627-643. doi: 10.1007/s40291-022-00613-2. Epub 2022 Oct 17. PMID: 36251245; PMCID: PMC9626425.

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