The Powerful and Novel NIST Hybrid Search for Unknown Identifications in GC/MS and LC/MS Analyses

by James Little, Mass Spec Interpretation Services

The NIST Hybrid search is a powerful and novel approach for the identification of unknowns in GC/MS and LC/MS analyses. It employs a hybrid library search composed of the standard identity search merged with the results of a neutral loss search.

I have done over 70,000 EI hybrid searches and routinely amazed at the results. It will infer structures not found in the standard identity search. Thus, It will greatly extend the utility of all your reference EI libraries.

It you want to learn more about the details, see my web site for videos, handouts, talks, etc. for both EI and MSMS applications:

https://littlemsandsailing.com/2020/10/excel-deltamass-table-for-hybrid-searches/

Wiley KnowItAll also developed a similar approach which they refer to as the Adaptive library search.

Видео The Powerful and Novel NIST Hybrid Search for Unknown Identifications in GC/MS and LC/MS Analyses канала james little