WG/GLIMPRINT Virtual Seminars, Arciero, Transplant and Therapy Modeling, June 26, 2025

Modeling Novel Immunoregulatory Treatments for Transplant Patients
Julia C Arciero, PhD
Indiana University

Successful organ transplantation is a lifesaving procedure, but it is met with serious risks including organ rejection, infection, and a compromised immune system. This study aims to identify new therapeutic strategies to yield transplant acceptance while reducing the reliance on immunosuppression. A previously developed ordinary differential equation model of the immune response to a transplant is adapted to incorporate the effect of immunosuppression in combination with the adoptive transfer of regulatory T cells. Known mechanisms through which calcineurin inhibitors (immunosuppressive drugs) preserve the transplant are simulated. The model is used to show that the combined use of adoptive transfer provides little additional benefit, even when tapering immunosuppression levels. Model simulations also demonstrate the impact of reducing the effect of immunosuppression on regulatory T cells, with the aim of reducing key mechanisms of immunosuppression but still achieving graft tolerance. The study demonstrates the utility of mathematical modeling in guiding future experimental studies of new therapeutic strategies in transplant immunology.

To learn more see:
Modeling the Potential of Treg-Based Therapies for Transplant Rejection: Effect of Dose, Timing, and Accumulation Site: https://www.frontierspartnerships.org/journals/transplant-international/articles/10.3389/ti.2022.10297

*Contents*
00:00 - Introduction
08:22 - Modeling Novel Immunoregulatory Treatments for Transplant Patients
56:13 - Questions and Discussion

For a copy of the slides for this video visit:
https://drive.google.com/file/d/1wv0rD1aTMkcAv8KnnRKJCJSxR5TBQzjx

Moderator: James A. Glazier

If you found this video useful, please check out our other videos on computational modeling, infection and immunology: https://youtube.com/playlist?list=PLiEtieOeWbMKh9VcQoinSwODcSZKMTGat

Please consider joining our IMAG/MSM WG on Multiscale Modeling and Viral Pandemics: https://www.imagwiki.nibib.nih.gov/content/msm-viral-pandemics-meetings

Please also consider joining the Global Alliance for Immune Prediction and Intervention: http://glimprint.org/

Видео WG/GLIMPRINT Virtual Seminars, Arciero, Transplant and Therapy Modeling, June 26, 2025 канала James Glazier