DNA Replication (Eukaryote) INITIATION - Origin Licensing - cdt1 recruits Helicase Double Hexamer

References/Resources: https://www.patreon.com/the_Crux

In this part-2 video on eukaryotic DNA replication initiation, we discuss the process of origin licensing. This is when cdt1 is recruited by orc6 and cdc6, and helps recruit two double hexamers at the origin of replication. This marks the completion of origin licensing as it moves through pre-replicative complexes. We dive into how all this is established and we also connect origin licensing to the cell cycle dynamics as well.

Jump to your favorite section:
00:00 Outline
00:36 mcm proteins
03:12 Helicase assembly
04:03 cdt1 and Single Hexamer
07:14 cdt1 and Double Hexamer

Patreon Page: https://www.patreon.com/the_Crux

DNA Replication Initiation videos (Eukaryotes)
Part 1 (Origin Recognition): https://youtu.be/Ze-7V42_wlo
Part 3 (Origin Firing): https://youtu.be/q9e6ST466mI

Complete DNA Replication playlist: https://youtube.com/playlist?list=PL0Ymnd-zt4IgLefDaeqicJbCBnbLqnDJ7

*Must watch playlists*
All videos on DNA Replication: https://youtube.com/playlist?list=PL0Ymnd-zt4IgLefDaeqicJbCBnbLqnDJ7
All videos on Transcription: https://www.youtube.com/playlist?list=PL0Ymnd-zt4Ij2VcAOHNUweftSElVsc-MX
All videos on Translation: https://www.youtube.com/playlist?list=PL0Ymnd-zt4IjAAAMlPLDIXbs692Yp14xa

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