Vitamin D2 supplements may quietly lower the body's vitamin D3 levels, meta-analysis finds

A new systematic review and meta-analysis in Nutrition Reviews pooled 11 randomized controlled trials covering 655 adults and found vitamin D2 supplementation cuts blood D3 by about 18 nmol per liter, sometimes below levels in people taking no supplement at all. Both forms are sold as vitamin D but are not interchangeable in the body. The authors recommend prioritising D3. Check the label: ergocalciferol is D2, cholecalciferol is D3.

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