Update

EMA approves Pfizer BioNTech vaccine

UK borders close

https://www.bbc.co.uk/news/uk-55391289

France closed its border with the UK for 48 hours

Dover closed

Kent Police, Operation Stack

Manston Airport site in Kent, 4,000 lorry park

About 10,000 lorries a day

Unaccompanied freight allowed

Eurotunnel, France

Eurostar, Belgium

Flights from UK suspended to more than 40 countries

Germany, Italy, Belgium, Irish Republic, Turkey, Canada, Switzerland, India, HK, Ireland, Israel, Saudi Arabia, Kuwait, Russia

Cases, + 35,928 + 33,364 = 2,073,511

Deaths, + 362 + 215 = 67, 616

Deaths, + 3,160 (7 days) = 76,287

Matt Hancock, new variant of the virus is getting out of control

London and south-east England

2020 12, N 501 Y mutation

https://www.sciencemediacentre.org/expert-reaction-to-pms-and-cmos-statements-about-new-restrictions-and-the-new-sars-cov-2-variant/

Asparagine (N) to Tyrosine (Y)

Receptor-binding domain

Replacing other variants

D614G

Aspartate (D) to Glycine (G)

Right place at the right time – founder effect

More contagious

? more virus in upper airway

September, first detection

November, London, about 25% of cases

December, London, over 60% of cases

Where did it come from?

High levels of genomic monitoring in the UK

Has spread from UK to Denmark, Australia, Netherlands

Accumulated number of global mutations, 12,000

Viruses entered the UK 1,300 times

Mink mutation

https://www.cogconsortium.uk/news_item/explainer-sars-cov-2-mutations-the-science-behind-the-mink-case/

Two amino acids deletion (69-70) same as 2020 12

Three amino acid replacements in position 453, 692 and 1229 (Y453F, I692V and M1229I) different to 2020 12

Tracker app

https://covid.joinzoe.com/data#levels-over-time

Official data

https://coronavirus.data.gov.uk/details/cases

Видео Update канала Dr. John Campbell